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Spümcø Inc. (now Spümtwo) is an American animation production company based in Los Angeles, California. The studio produced three traditionally animated series, two Flash-animated cartoon series, two music videos, five animated shorts, and a comic book. The company also went on to produce content for a few animated spots and commercials. It has won several awards, including an Annie Award for Best Animated Short Subject, for the Björk music video, "I Miss You".

Spümcø was founded in 1988 as a small office facility in the heart of Hollywood. The company name was claimed to have been derived from the name of animation pioneer Raymond Spum. Only a few short months after Spümcø's founding, Nickelodeon announced that they were looking for new cartoons. A concept claimed to be "revived" by then-president of Nickelodeon, Geraldine Laybourne, was that of "creator-driven cartoons". Spümcø co-founder and then-president John Kricfalusi sold The Ren & Stimpy Show to Nickelodeon in 1988, which became Spümcø's first original animated series production. The Golden Age of American animation, like the 1940s cartoons by Bob Clampett and Tex Avery to name a few, served for inspiration for the bizarre expressions and artwork for which Spümcø became well known.

The Spümcø headquarters were located in Los Angeles, west of Paramount Studios. Amy Harmon of The New York Times said that "the not-quite-underground headquarters" was "a nondescript building."

In 2005, Spumco closed in 2005 after a lawsuit with Carbunkle Animation.

In 2016 and 2017, two separate announcements were made about new animation studios being formed. For more information, see Spümtwo.

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